Whilst low-depend MBL rarely progresses to CLL, substantial-count MBL progresses to CLL demanding therapy in a charge of 1% to two% annually. Large-count MBL is distinguished from Rai 0 CLL dependant on whether the B-cell rely is higher than or beneath five × 109/L. Even though folks with both equally large-rely MBL and CLL Rai stage 0 are at elev